In hollow fiber tangential flow technology, the fluid flows parallel to the membrane, generating transmembrane pressure vertically, small molecules permeate through, and macromolecules or particles are sweep away by the tangentially moving fluid, thereby mitigating membrane fouling, prolonging process time and capacity. It is an effective method for concentration, desalination, and buffer exchange of bio molecular and virus solutions. The volumes processed can vary from a few milliliters to tens of thousands of liters.
Hollow fiber filters can be widely used in various areas of pharmaceuticals and life sciences industry, including antibodies, gene and cell therapy, mRNA, human & animal vaccines, blood products, albumin and islet recombinant proteins, traditional medicine injections, traditional small molecule drugs, biochemical and tissue extracts.
Applications
The application of hollow fibers covers many critical steps in biological products and pharmaceutical processes, including protein purification and concentration, virus purification and concentration, harvest of protein precipitates, harvest of bacteria, endotoxin removal, bioburden reduction, cell perfusion culture, adherent cell culture in fibers, graphene quantum dots process, and other special applications.