FiberCell Systems hollow fiber bioreactor cartridges provide an in vivo-like 3-D cell culture environment that eliminates the need for cell splitting and passaging while concentrating secreted products 10x to 100x higher than standard 2-D culture.
Available Cartridge Variations:
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Small Cartridges:
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Cat #C2025: PVDF fiber with 0.3 um pore size and 80 cm2 outer surface area. Allows attachment of matrix proteins, cytokines, and antibodies. Ideal for endothelial cell culture under shear.
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Cat #C2025D: Polysulfone fiber with 20 kD MWCO and 450 cm2 surface area. Designed with one wrap of oxygenation tubing to reduce dead volume.
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Medium Cartridges:
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Cat #C2008: Low MWCO (5 kD) hydrophilic polysulfone fiber for recombinant proteins (25 kD to 100 kD). Supports adherent and suspension cells (CHO, HeLa, 293).
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Cat #C2011: High MWCO (20 kD) hydrophilic polysulfone fiber for monoclonal antibodies and larger proteins (100 kD+). Cartridge of choice for PK/PD studies.
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Cat #C5011: Same build as C2011 but with 2X oxygenation capacity, designed specifically for hybridoma scale-up.
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Cat #C8008 / CB008: Low MWCO (5 kD) cellulosic fiber offering solvent resistance and low non-specific binding for PK/PD studies.
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Large Cartridges:
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Cat #C2003: Low MWCO (5 kD) hydrophilic polysulfone fiber with 1.2 m2 surface area. Produces 5-20 mg recombinant protein daily in a 60 mL ECS volume.
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Cat #C2018: High MWCO (20 kD) hydrophilic polysulfone fiber for large recombinant proteins. Supports up to 5×10^10 cells in a 60 mL ECS volume.
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